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The phrase "vastly differing" is correct and usable in written English.
It means that there is a significant or considerable difference between things. Example: The two candidates' opinions on healthcare reform were vastly differing, causing much debate among voters.
Exact(59)
Two very different men, then, with vastly differing philosophies.
We describe the generation of multiple, unique small peptides nine to thirty-four acids acins in length which, when labeled with the radioisotope 32P, bind with vastly differing efficiencies to cell lines derived from different colon adenocarcinomas.
Button tried two different sets of the 'hard' tyre in practice with vastly differing results.
There were vastly differing accounts of the toll.
The managers can have vastly differing backgrounds, typically in nursing or social work.
It is not intended to compare countries of vastly differing G.D.P.'s.
The ferment on Tuesday exposed vastly differing views of the program between immigrant advocates and Obama administration officials.
Given that the workshop is now so omnipresent as a feature of the English-speaking world, it's unlikely to result in vastly differing poetries.
But it can be a very fine line between corrective surgery and cosmetic, and even within a family there can be vastly differing opinions.
Or, with the government and opposition presenting vastly differing accounts of what is happening in Syria, do we chalk this one up to more misinformation?
Cementite is harder and stronger than ferrite but is much less malleable, so that vastly differing mechanical properties are obtained by varying the amount of carbon.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com