Indeed, ∼200 300 estrogen-responsive genes have been identified in the human genome, suggesting a vast number of potential functions for estrogen [ 13, 14].
Tumor cells respond to changes in oxygen via delegating the transcriptional factor HIF-1 α for orchestrating vast number of its essential cellular functions.
Most importantly, 60 unique metabolites could be associated and mapped to vast number of diseases and biological functions (Supporting Information Figure S-16 and Spreadsheet S-2).
This, combined with proteome studies and the presence of some of the genes in fosmid libraries, provides a strong indication that the vast number of genes with unknown function play a vital role in the organism's environmental response.
As COMT regulates neuronal and non-neuronal cellular pathways important for a vast number of basic and complex biologic functions, reduced COMT leading to elevated catecholamine levels could also be beneficial.
Given the vast number of miRNAs and the diverse functions in different biological processes observed in the relatively small number of miRNAs studied thus far, it is apparent that many new and unanticipated functions of miRNAs in normal muscle development, function and disorders are waiting to be discovered.
Since then, a vast number of publications describing the structure and function of this transcriptional co-regulator have been published (reviewed in [ 2]).
The transcriptome patterns provided will also aid in making functional interpretations for the vast number of genes that have poorly known biochemical and developmental functions.
Furthermore, ubiquitination is indispensible in regulating biological functions of a vast number of proteins [35].
Phosphorylation plays a key role in a large set of signal transduction pathways and is known to regulate the functions of a vast number of different proteins.
