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Ectopic expression of Dp53 in the eye (GMR>Dp53) induces vast cell death and produces small and rough eyes with fused ommatidia (Supplementary Figure S2a).
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Whether the increase could also reflect an immune response towards the vast amount of cell death in the tissue is still open to speculation.
Importantly, despite an increased number of autophagosomes in septic samples, hepatocytes did not appear to be committed to cell death and the vast majority of mitochondria in both sham and CLP groups appeared normal.
The vast majority of these were upregulated transcripts of genes involved in cell death, stress responses and differentiation.
Therefore, functional loss of VHL observed in the vast majority of CCRCC increases anti-apoptotic protein expression, rendering these tumour cells more resistant to normal cell death processes.
Cell Death.
Cell Death Differ 2017 Feb 24.
J Cell Death.
Cell Death Dis.
Programmed cell death.
Cell Death and Diff.
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