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MAPK are highly conserved enzymes regulating a vast array of cellular functions, including cell survival, proliferation, and differentiation, as well as inflammation and stress responses [9, 10].
Integrins are a class of cell surface receptors that play important roles in a vast array of cellular and physiological processes, ranging from embryonic development to immunity to tumor metastasis.[13], [14] Integrins form heterodimeric, transmembrane receptors that consist of an α subunit non-covalently associated with a β subunit.
Although exosomes are implicated in a vast array of cellular functions, and have been considered a cell-free source of tumor antigens when secreted by cancer cells [11], [18], they have been lately hypothesized to foster immunosuppression in tumor-bearing hosts [3], [9], [12], [16], [30].
G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes.
Calpains are members of the highly conserved calcium-dependent proteases capable of cleaving a vast array of cellular proteins [ 141].
Post-translational modification of substrate proteins by small ubiquitin-like modifier (SUMO) regulates a vast array of cellular processes.
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Our model has the advantage of permitting systematic statistical analyses of synergy employing generic laboratory cellular screening experiments involving a vast array of genetic cellular backgrounds.
Proteases and peptidases are involved in a vast array of fundamental cellular processes, including cell growth, survival, motility, death, and differentiation, and can be important players in multicellular systems such as angiogenesis, inflammation, and immunity.
Over the past decade it has become clear that non-coding RNA (ncRNA) molecules have a major role in a vast array of diverse cellular processes.
HIF-1 is implicated in the regulation of a vast array of genes that control multiple cellular functions such as angiogenesis, glucose metabolism and cell survival.
While adding in auxiliary data (such as incorporating Gene Ontology (GO) associations into clustering scores) may aid in finding true structures with biological impact faster, the problem remains that publicly available databases remain incomplete due to the vast array of possible functionality at the cellular level [ 19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com