In this work, we show that the vast majority of SUL1 amplification products that arise in sulfate-limited growth are in situ inverted amplicons with unique junctions coinciding with genomic sequences that consist of short, interrupted palindromes, a result we first discovered for a single clone (Araya et al. 2010).
Studies comparing wild-type and mutant strains of yeast demonstrated that in regions of increased DNA copy number (i.e. genomic amplifications), the vast majority of genes that mapped within the amplified region had increased expression when compared to gene expression in non-amplified regions [ 1].
A loaf of bread, a jug of wine, and Puccini: it's Met in the Parks season again, when happy picnickers can appreciate the sight and sound of distant divas filtered through an amplification system over vast distances.
SELEX involves sequential rounds of selection and amplification from a vast pool of nucleic acids (1014 molecules) for ligands (aptamers) that bind with high affinity to target molecules.
Centrosome amplifications are found in the vast majority of human malignancies, but whether benign lesions also contain centrosome defects is still controversial.
To date, centrosome amplifications are found in the vast majority of human malignant tumors, including those of the pancreas, the prostate, the breast, the lung and the colon [ 4, 5].
"Amplification is a huge part of that.
The vast majority of these isolates did not show any amplification for the cpsA internal positive control (data not shown).
*For lcyE 5′TE the vast majority of the inbred lines (> 70%) did not yield any amplification, and thus scored as 0' alleles to represent no amplification, not deletion.
