hemorrhages were seen in children during a second dengue infection as a late consequence of uncorrected vascular permeability shock (whether detected or not).
While both anaphylaxis and DENV infection can ultimately result in systemic dysregulation of the vascular system, shock, and multiple organ dysfunction, variation in the clinical presentation of these responses raises questions about the similarity between the two mechanisms.
Children may be more susceptible to vascular permeability shock-related g.i.i
In sepsis and septic shock, vascular injury is central and prompted by different actors with overlapping kinetics, leading to difficulties in deciphering a sequential order [97].
When sepsis proceeds to hypodynamic shock, vascular responsiveness to ADM fades, suggesting that reduced ADM function could be causal for progression of the disease.
CD8+ T cells may mediate circulatory shock, vascular permeability changes, and edema in the brain during PbA infection [38].
Infection is characterized by acute high-fever, vascular collapse, hypotension, shock, and multiple organ failure, as well as the short course of disease (acute death occurs within ∼2 hours of infection) and high mortality (97.4%)[3], [4].
Furthermore, intestinal IR may be looked at as a common pathway in several pathologies, where temporary reduction in flow may result from inherent vascular disease (thrombosis, shock, embolism, vasculitis) or from inflammatory diseases affecting perfusion.
Following this, the hypotensive phase is characterized by thrombocytopenia, vascular leakage, and shock [ 64].
After further investigation, inhibition of autophagy may serve as a potential therapy for vascular leakage in shock patients.
