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The other route of chemical communication to the pars distalis is found in many fishes and in all terrestrial vertebrates; it is a vascular route that depends upon the median eminence, which lies at the front end of the neurohypophysis (see Figure 2).
The parasite Entamoeba histolytica colonizes the human intestine causing amoebic colitis and disseminates through the vascular route to form liver abscesses.
Since neurotropic viruses that enter the CNS through the vascular route may damage the blood-brain barrier it would be interesting to investigate in neonate mice, early and late in the disease, the integrity of the blood brain barrier in order to clarify this possibility.
However, since intranasal inoculation of these viruses in mature albino Swiss mice did not induce encephalitis but exhibit antigenic immunolabeling in non-symptomatic subjects (not illustrated), it remains an open question whether or not vascular route remain an alternative pathway for neuroinvasion in neonatal period.
Thus the infectious inoculum must spread to the gut by a vascular route, a direction opposite to that generally assumed.
Contrary to this, there are safe methods which deliver the drug through vascular route which infuse and spread in larger portion of the brain.
Similar(47)
Inoculation of human bronchial epithelial cells, endothelial progenitor cells, bone marrow-derived mesenchymal stem cells, and lung fibroblasts via airway or vascular routes into small, excised segments of the decellularized lungs demonstrated that normal lung scaffolds robustly supported initial engraftment and growth of each cell type for up to one month.
10.7554/eLife.07847.018 Figure 8. Lung monocyte-derived cells survey both airways and vascular routes whereas dendritic cells (DC) survey only airways.
The sites of tumour development for 6 rat tumours injected into syngeneic rats via different vascular routes was determined.
20– 22 STM could occur via spread of tumor cells through lymphatic channels draining the primary tumor or through perineural or vascular routes.
Whilst amyloid clearance was achieved, increased CAA and CAA-associated vasculopathy and amyloid-related imaging abnormalities (ARIA) suggested that plaques were removed from the brain by vascular routes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com