Thus, expectations about weather (and other varying determinants of supply and/or demand) are likely to affect both supply and demand, in such a way that weather changes may not have the expected consequences.He proposed a statistical tool, the vector autoregression (VAR), as a solution to this problem.
Second, in analyses such as these which only utilise one time-point, there is an inability to maximise the information provided by time varying determinants of non-response such as age.
This facilitates the use of detailed analyses with the drug as a time-varying determinant [ 335].
Unlike constant features such as sex and certain genetic traits, drug use is essentially a time-varying determinant.
The association between metformin and cancer was analyzed using Cox proportional hazards models, with duration of cumulative drug use as a time-varying determinant, as described earlier (22).
The association between the risk of cancer in those using metformin compared with those using sulfonylurea derivatives was analyzed using Cox proportional hazard models with cumulative duration of drug use as a time-varying determinant.
In this paper, we discuss the importance of an adequate definition of drug exposure in pharmaco-epidemiological research and how this time-varying determinant can be analyzed in cohort studies.
In this paper, the authors discuss the importance of an adequate definition of drug exposure in pharmaco-epidemiological research and how this time-varying determinant can be analyzed in cohort studies.
The association between insulin and cancer was analysed using Cox proportional hazard models with duration of cumulative drug use as a time-varying determinant, as described by Stricker and Stijnen [ 38].
In a cohort of incident users of insulin, the association between insulin glargine and other insulin analogues, respectively, and cancer was analysed in comparison with human insulin using Cox proportional hazard models with cumulative duration of drug use as a time-varying determinant.
In a Cox proportional hazards regression analysis with drug exposure as a time-varying determinant [ 16], the exposure status x1[ tj] on the index day t j of the case number j, is compared to the exposure status of all other cohort members on the same day of the follow-up.
