We also discuss the various types of mutations that might underlie this fatal neurodegenerative condition and outline some of the strategies that might be useful in untangling them.
To our knowledge, this is the first report to demonstrate that the CRISPR/Cas system can be used for accurate KI targeting with ssODNs in rats, thereby recovering disease-associated phenotypes of various types of mutations, such as SNPs, indels and large genomic structural variations.
These alterations include various types of mutations, translocations, and copy number variations.
Various types of mutations have been noted in GHR, leading to GHR extra-cellular domain inactivation.
DOI: http://dx.doi.org/10.7554/eLife.03032.002 Eukaryotic cells are constantly at risk for various types of mutations.
TP53 mutation is a strong independent marker for survival in breast cancer with some heterogeneity in the clinical phenotype of various types of mutations.
The occurrence of various types of mutations is comparable to other studies of this size [ 21, 24, 26, 27], but some differences are also apparent.
In this work, we followed the observation that prediction performance differs among various types of mutations based on the accessible surface area or secondary structure.
Recent developments of large-scale sequencing in the cancer genome have exploited hundreds or thousands of various types of mutations [ 1], such as DNA sequence alterations including point mutations, nucleotide mutations, and genomic rearrangements [ 2].
Multiple studies in various human and mouse cell lines showed that the CRISPR/Cas9 system is a powerful genetic tool able to generate various types of mutations (Jinek et al. 2012; Cong et al. 2013; Jinek et al. 2013).
