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All three support multiple data formats that are used to represent various types of alterations.
Each gene profile contained 48 features measuring various types of alterations in cancer (Additional file 2).
In cancer cells, this becomes even more complicated due to various types of alterations (e.g. DNA mutations, genome rearrangement, epigenetic changes, and pathway alterations).
Constitutive PI3K AKT pathway activation can result from various types of alterations in this pathway, including mutation or amplification of receptor tyrosine kinases (such as EGFR and HER2), mutation of Ras, mutation or amplification of PIK3CA (the p110 α catalytic subunit of PI3K) and inactivation of the tumour suppressor gene, PTEN (Yuan and Cantley, 2008).
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Results revealed that Hyperion data prove to be powerful in discriminating and mapping various types of alteration zones while the data were subjected to adequate pre-processing.
Since its introduction, high-resolution melting (HRM) analysis has been used for genotyping of various types of sequence alterations.
Three-dimensional microscopic observations clearly show that each shoe and flooring specimen had experienced various types of surface alterations and surface failures that were evolved throughout the entire tests.
A useful repertoire of proteomics technologies is currently available for disease-related applications, though further technological innovations would be beneficial to increase sensitivity, reduce sample size requirements, increase throughput, and more effectively uncover various types of protein alterations, such as post-translational modifications.
Various types of microcirculatory alterations associated with different states of cardiovascular compromise have been classified based on direct observation of the microcirculation in various organ beds [ 36].
Deregulated MYC expression resulting from various types of genetic alterations leads to constitutive MYC activity in a variety of cancers and promotes oncogenesis (Dominguez-Sola et al. 2007).
Various types of DNA alterations have been reported in cfDNA including point mutations, microsatellite instabilities, loss of heterozygosity, and DNA hypermethylation [ 24, 25].
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