Exact(12)
MOA has been used predominantly for understanding the assessment of cancer risk, but because dosimetry and other mechanisms of toxicity are shared across various toxic effects, it is applied increasingly for noncancer risk assessment as well (Bogdanffy et al. 2001; Guyton et al. 2008).
Mercury (Hg) is a well-known heavy metal and causes various toxic effects.
Low interest rates may be insufficient to assure that this occurs and may have various toxic effects, including bubbles in asset prices and misallocations of investment.
Intracellular ROS were reported to be a crucial indicator of various toxic effects from NPs [53].
However, they are potentially hazardous for human health, because they exhibit various toxic effects in both in vitro and in vivo experiments [118 122].
Nano-TiO2 was shown to cause various toxic effects in both rats and mice; however, the molecular mechanism by which TiO2 exerts its toxicity is poorly understood.
Similar(48)
This alkali element and its salt, at its higher doses, may lead to various side effects or has several toxic effects after prolonged therapeutic use.
Currently marketed anticancer medications have increasing problems of various toxic side effects and development of resistance to their action.
Lack of selectivity and short blood circulation time which cause various toxic side effects are also issues of major concern [ 42].
Most small-molecule anticancer drugs currently in clinical use, including cisplatin, doxorubicin and paclitaxel, are inherently associated with a lack of tumor selectivity and short blood circulation time, which causes various toxic side effects.
Overall, induction and persistence of DNA damage during the period of active growth may interfere with cellular programming and development, and therefore predispose younger individual to various toxic radiation effects, including tumors and cognitive deficits.
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