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Finally, we summarize the applications of nanotopography to various tissues, which are classified into four types depending on their functions: protective, mechano-sensitive, electro-active, and shear stress-sensitive tissues.
MIF is a unique proinflammatory cytokine, found preformed in various tissues, which plays a critical role in immune response and inflammation [ 10].
Mast cells are primarily located in mucosal and perivascular areas of various tissues, which play an important role in body-defense processes.
CT is the reference imaging modality for radiation treatment planning as it provides electron density information of the various tissues which is needed for the dose calculation algorithms.
In Table 2, we summarized the result of GO analysis on various tissues, which shows that the genes involved in these network motifs are related to the late period of embryogenesis.
Moreover, αvβ3 may have different function in various tissues, which may partly explain the divergent results of αvβ3 expression linked to bad prognosis in other cancers, such as breast cancer and melanoma [ 27, 28].
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Human mesenchymal stem cells are currently being studied extensively because of their capability for self-renewal and differentiation to various connective tissues, which makes them attractive as cell sources for regenerative medicine.
MSCs have been reported from various human tissues, which exhibit the expression of above mentioned cell surface markers along with positive expression of CD29, CD44, CD146, CD140b specific to tissue origin.
Recent researches have revealed that acting as tumor suppressive or oncogenic genes, miRNAs exhibited a special expression profile in various cancerous tissues, which can be precisely detected and quantified by qRT-PCR in tissues and circulating samples, even in urine or saliva samples [ 10, 54].
Emerging evidence has implicated that the aberrant expression of 2-Cys Prx isoform proteins are correlated with several human diseases including cancers, and the elevated Prx expressions are discovered in various cancer tissues, which is possibly due to the adaptive response to oxidative stress facilitating cancer cell growth.
Although beyond the scope of the work presented here, it will ultimately be very informative to examine changes in gene expression for PCN or related mutants in the various tissues in which these genes are normally expressed.
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