The developmental specificity of these proteins results from their differential regulation of various target genes.
Homeotic genes of Drosophila melanogaster such as Ultrabithorax (Ubx) and Antennapedia (Antp) have long been thought to select metameric identity during development by controlling the expression of various target genes.
To develop a technique for simultaneous detection of various target genes in Roundup Ready soybean by combining multiplex PCR and low-density DNA microarray.
The architectural transcription factor TCF-1 interacts directly with β-catenin and activates transcription of various target genes that are important for early development and carcinogenesis.
In order to alleviate this step, we developed a strategy aimed at the rapid and efficient generation of genetically modified cell lines with conditional, inducible expression of various target genes.
Typically, quorum sensing bacteria produce and release small chemical signals, and at a high population density, the accumulated signals interact with cognate receptors to induce the transcriptional expression of various target genes including those encoding production of virulence factors.
One extreme situation is that of a fully location–specific TF, one that affects transcription of its various target genes only if it is bound within a narrow range of distances from the respective TSSs.
Next step was to examine the role of downstream mediator of the MAPK pathway, the transcripotion factor NF-κB, which translocates into the nucleus upon activation to initiate transcription of various target genes [50].
They act via steroid hormone receptors (SR), which belong to the nuclear receptor superfamily of ligand-activated transcription factors and serve as regulators of various target genes [1] [3].
The Wnt signalling pathway is induced by binding of Wnt family proteins to cell surface receptors, leading to stabilization of cytoplasmatic β-catenin, translocation of this regulatory protein into the nucleus, formation of a complex with transcription factors of the Tcf/Lef family and subsequently the activation of various target genes [13].
