The increased DNA methylation levels in non-cancerous gastric mucosae with H. pylori infection were observed in various but specific genes, including a small number of tumor-suppressor genes, such as p16, ANGPTL4, and FHL1, and a large number of passenger genes [ 44– 44].
Also, although alcohol's general effects on DNA methylation may be similar across various tissues, the specific genes affected by this regulation may differ depending on cell type.
More specifically, the expression of various oocyte-specific genes was demonstrated to be essential at a specific time during early folliculogenesis but little is known exactly about which granulosa cell factors play a specialized role in follicular development.
To further investigate the regulatory role of vosA in conidiation, we examined the mRNA levels of various development-specific genes.
C/EBPβ and C/EBPδ then elicit the expression of C/EBPα and the PPARγ (Peroxisome proliferator-activated receptor γ) isoform PPARγ2, two transcription factors working in a cooperative manner to promote the expression of various adipocyte-specific genes [13].
Many more DAAs are being developed against various virus-specific genes and proteins and will soon reach the clinic.
In situ hybridization for various muscle-specific genes placed cited3 into a gene regulatory network, where it acts downstream of myoD/myf5 but upstream of mef2c.
No differences were observed between primary HFLCs and mature human hepatocytes in terms of albumin production and the mRNA levels of various liver-specific genes.
In particular, HNF-4 is described to be one of major transcription factors for various liver-specific genes involving in the regulation of protein and lipid synthesis, glucose and drug metabolism (Kimata et al. 2006; Crestani et al. 2004).
It has been reported that parallel expression of various thyroid-specific genes (NIS, Tg, TPO, TSHR, TTF1 and Pax8) is inversely correlated with differentiation and malignant phenotypes [ 22, 23].
