There is evidence that many lncRNAs act as scaffolds that regulate the molecular (that is, protein, RNA, and DNA) interactions required for various signalling networks, which is accomplished, in part, via interactions with chromatin-modifying complexes and the epigenetic regulation of the expression of multiple genes (Mercer et al, 2009; Ponting et al, 2009; Li et al, 2013b).
(In such cases, researchers typically try to predict the impact of a mutation by looking at how it affects the structure and function of the protein the gene produces, and then examining the role this protein plays in the cell's various signaling networks). Along with the database, Foundation Medicine is building a user interface to help oncologists interpret information.
Intractable cancers such as triple-negative breast cancers have limits to treatment with standard therapies because of DNA damage response highly interconnected with various signaling networks [1 3].
The binding diversity of IDPs plays important roles in the establishment, regulation and control of various signaling networks.
Alternatively, the intrinsic miRNA expression pattern may vary between different types of breast cancer, resulting in differing activation of various signaling networks.
They were organized in biochemical pathways and in a wider metabolic network, which was self-dependent on various genetic and signaling networks for its regulation (Dumas, 2012).
Salicylic acid (SA), jasmonate (JA), and ethylene (ET) contribute to responses to biotic stresses by influencing various signalling pathways with complex networks of synergistic and antagonistic interactions [ 2].
Several PLC members have been implicated in various cellular processes and signaling networks, triggered in response to a number of environmental cues and developmental events in different plant species, which makes them potential candidates for genetically engineering the crop plants for stress tolerance and enhancing the crop productivity.
Genome programs and high-throughput screenings have greatly contributed to the construction of signaling networks in various model organisms, ranging from invertebrates to mammals.
The complex network data demonstrates a high number of interactions between differentially expressed proteins and various signalling proteins.
Posttranslational modifications (PTMs) of proteins are crucial for understanding the dynamic proteome and various signaling pathways or networks in cells.
