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Residue closeness is distinct from various sequence and structure measures and can thus complement them in identifying key protein residues.
Finally, the "Statistics" option offers various sequence and structure-based statistical analyses of SNPs distributions across kinase genes.
ConSurf and ResBoost are both based on evolutionary conservation, various sequence, and structure features.
The investigations have been carried out on various sequence and structure based features as well as molecular dynamics simulations.
The computation results include possible catalytic residues ranked by their scores, which are calculated based on various sequence and structure features.
These include, among others, global structural (fold) similarity, various sequence and sequence-profile based similarity methods, reverse templates and genome co-localization.
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This could be the underlying reason for the deviations between the actual representative plots of the various sequences and their fitted curves observed in several graphs.
Widespread implementation of this diagnostic imaging has raised the need to optimize the various sequences and to further develop novel sequences.
Nevertheless, the mass spectrum for each peak was still too complex to be completely interpreted, as each peak contained a mixture of multiple components having various sequences and degrees of sulfation.
Specifically, (1) miRNAs are prone to detected homologous miRNAs with higher level of sequence similarity, (2) miRNAs are prone to cluster together with close physical distance, (3) some miRNAs are located on sense and antisense strands of specific genomic regions, and (4) miRNA locus can generate multiple isomiRs with various sequences and expression levels, and so forth.
Although the bootstrap value supporting this α1-I clade in addition to the α1-III and α1-VIII clades are fairly low 48-600%), they are robust when including various sequences and reproducible between different studies ([ 13, 57] and this study).
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