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As mentioned above, in several cases we could also fix the relative sign of the various regulatory interactions in the FFLs so that we could distinguish between coherent and incoherent FFLs.
Although the exact mechanism how the lncRNA interacts with different partners is still not known, our data provide a startup point to the community to understand the various regulatory interactions of lncRNAs with their respective partners.
Most of these subtype-specific hubs have no significant CNA, and are reached only through network expansion, suggesting that chromosomal aberrations can drive cancers by indirectly manipulating hub gene expression through various regulatory interactions, such as transcriptional regulation and protein modification.
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Interestingly, it possesses only one (N-terminal) of the two nuclear localization signals that are seen in other mammalian poly(A) polymerases, and lacks the C-terminal domain that is involved in various regulatory modifications and interactions.
Kar et al. review the various regulatory mechanisms and interactions of DNMT1, the maintenance methyltransferase.
This dynamic behaviour results from regulatory interactions at various levels.
The database provides web-based interactive search and visualization tools that can be used to build subnetworks and to identify known and novel regulatory interactions across various regulatory layers.
The spatial relationships provide evidence for interactions among various regulatory elements.
The anti-oxidative system includes enzymatic [superoxide dismutase (CuZnSOD, MnSOD), catalase, glutathione peroxidase] and non-enzymatic [Vitamin C, Vitamin E, carotenoids, thiol antioxidants (glutathione, thioredoxin, and lipoic acid), flavonoids, selenium, and others] antioxidants, as well as the antioxidant interactions with various regulatory factors such as NF-κB, AP-1, and Nrf2 [ 47].
Concomitantly, we used various network inference algorithms to identify putative regulatory interactions and we integrated all predictions to construct a consensus gene regulatory network that is TGRL lipolysis product specific.
Thus, the observed interactions between Mcm2-7 and the various regulatory factors may target key enzymatic activities, either DNA unwinding or regulation of the Mcm2/5 gate.
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