Exact(4)
Studies of DNA-repair defective cell lines have shown that various proteins implicated in nucleotide excision repair (NER), homologous recombination (HR), translesion DNA synthesis and Fanconi anemia (FANC) participate in the detection and repair of ICLs [4], [5].
TDP-43 associated with various proteins implicated in RNA metabolism, including proteins involved in pre-mRNA splicing, translational control and the miRNA pathway.
We have also demonstrated that piceatannol, a resveratrol analog metabolized by the cytochrome p450 enzyme CYP1B1, enhances the effects of CDDP in various ovarian cancer cell lines and inhibits various proteins implicated in cancer progression and chemoresistance.
siRNA pool 17 represents an On-Target plus siRNA pool from Dharmacon (Thermo Fisher Scientific, Lafayette, CO, USA) We have shown that NBPF1 can act as a tumor suppressor by inhibiting the cell cycle, by cell death induction or by expression modulation of various proteins implicated in cancer.
Similar(56)
Furthermore, mutations in various genes encoding proteins implicated in various aspects of mitochondrial function can also lead to an increased lifespan [ 9, 17].
In particular, rrm's are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs.
They occur in ill-defined reverse-transcription- and pre-integration-complexes (RTC, PIC) with various host and viral proteins implicated.
Wnts constitute an important family of vertebrate genes that encode secreted signaling proteins implicated in various developmental processes (patterning of the neural tube, neuronal differentiation), and are extensively conserved through evolution.
A strikingly high proportion (18.6%) of the overall differentially expressed mRNAs of known function were found to encode for proteins implicated in various mitochondrial processes, revealing mitochondria pathways dysregulation specific to HIBM.
One striking feature of the network was the abundance of deletion mutants identified that encode proteins implicated in various aspects of translation.
The high degree of association between intrinsic disorder and many proteins implicated in various maladies is due to structural and functional peculiarities of IDPs and IDRs, which are typically involved in cellular regulation, recognition and signal transduction.
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