Sentence examples for various proinflammatory genes from inspiring English sources

The molecular inflammation hypothesis of aging proposes that redox dysregulation causes an age-related activation of NF-κB and its signaling to upregulate various proinflammatory genes.

C/EBP- β on its turn elevates expression of various proinflammatory genes.

IL-1 β and IL-18, are important representatives of this family, inducing expression of an array of various proinflammatory genes and play a central role in innate and acquired immune response [ 14, 15].

NF- κB activation is markedly induced in IBD patients and through its ability to promote the expression of various proinflammatory genes, NF- κB strongly influences the course of mucosal inflammation [ 76, 77].

NF-κB activation occurs via phosphorylation and subsequent activation of MAPKs, followed by degradation of IκB bound to NF-κB, resulting in the translocation of NF-κB from the cytoplasm to the nucleus to promote the expression of various proinflammatory genes [ 6, 11].

DAMPs activate pattern recognition receptors (PRRs) and trigger various signaling cascades involving the activation of the transcription factor NF-κB, and subsequently the transcription of several proinflammatory genes [ 6].

Several proinflammatory genes exhibited this expression pattern.

FOXO1 promotes inflammation by increasing expression of several proinflammatory genes.

In MS, both NF-kB and AP-1 are activated and induce the expression of several proinflammatory genes and the production of proinflammatory molecules.

Finally, to validate the modeling results, we performed experiments measuring various key proinflammatory gene expressions in MEF and 3T3 cells for TNF stimulation.

Methods: Time course changes of the expression of genes for various proinflammatory cytokines and Reg were investigated after induction of gastric mucosal lesions in rats.