Expression array analysis of TBNC has revealed multiple subtypes, each with various potential targets [ 31].
Such therapy consists of combinations of the therapeutic approaches directed against various potential targets.
Various potential targets have been associated with its antitumor activity (Nikolovska-Coleska et al, 2004; Ahn et al, 2007; Dai et al, 2009; Joy et al, 2010); however, the antiangiogenic properties of embelin have not been explored further.
In order to clarify the mechanisms underlying the enhanced proliferative activity of the colon epithelial cells in the presence of adiponectin deficiency, we investigated the expression levels of various potential target proteins in colonic specimens prepared from the WT mice and KO mice under the high-fat diet.
"We've identified several potential targets".
Previous studies identified several potential targets of miR-195, including BCL2, AKT3 and FGF2, and they were implicated in the functions of miR-195 in various cell types.
The present review article briefly reviews the molecular biology and biophysics of mitochondrial bioenergetics, which then serves as a platform for identifying the various potential off targets for drug-induced mitochondrial toxicity.
A functional validation assay was performed by cotransfecting in human lung fibroblasts (WI26) synthetic miRNAs and engineered expression constructs containing the coding sequence of luciferase upstream of the 3'UTR of various potential mRNA targets.
Various potential drug targets have been reported to improve AD-associated pathological features such as acetylcholine esterases [ 9], NMDA receptor [ 10], and apolipoprotein E4 (ApoE4).
Previous studies have revealed various potential molecular targets responsible for the anticancer actions of BBR, such as DNA topoisomerase [ 30], HIF-1α [ 31], wnt signaling pathway [ 11].
Molecular studies in recent years have highlighted various potential therapeutic targets in HCC, including VEGF and FGF, EGFR, HGFR/c-Met, IGFR, survivin, Wnt signaling, Src signaling, the Ras/Raf/p38 MAP kinase (MAPK) pathway, and the PI3K/AKT/mTOR pathway [ 6, 8, 9].
