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The switch from an M2 to an M1 promoting environment during atherosclerosis progression may impede apoptotic cell clearance as M2 cells have greater capacity for efferocytosis [90] (Figure 1); this is through various pathways such as the expression of MR [91] and up-regulation of MER proto-oncogene tryosine kinase (MERTK) (on M2c), which is not induced on M1 macrophages [49],[92].
It was involved in various pathways, such as heart development, EGFR1 signaling pathway, insulin signaling, regulation of IFNA signaling, and interferon alpha/beta signaling, and others.
Various pathways such as glycolysis reported previously (Mathupala et al, 1997; Unwin et al, 2003; Perroud et al, 2006, 2009) were confirmed by our data.
On binding to ECM, integrin 5α regulates diverse functions in tumor cells including migration, invasion, proliferation and survival through activation of various pathways such as MAPK.
The 5-HT1B receptor, in particular, has been reported to modulate neurotransmission in various pathways, such as the retinocollicular (Mooney et al. 1994), retino-suprachiasmic nuclear (Pickard et al. 1999), and thalamocortical (Laurent et al. 2002) pathways.
Another 42 unigenes were genes related to various pathways, such as alanine aminotransferase, ADP-ribosylation factor, glucose-6-phosphate 1-dehydrogenase, acetyl-coenzyme A carboxylase, and alcohol dehydrogenase2 (Table 2).
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Consistently, IS activates various signaling pathways, such as JAK/STAT3 and PI3K/AKT/mTOR, in several retinal cell types.
As a result, we identified a number of essential genes for the cell growth across various functional pathways such as photorespiratory cycle, Calvin cycle, GS-GOGAT cycle and sucrose metabolism as well as certain inter-compartmental transporters, which are mostly in good agreement with previous experiments.
Various metabolic pathways (such as those involved in amino acid metabolism) were also observed to be enriched in deregulated genes in our study, (FDR <0.01).
Corneal epithelial wound healing is orchestrated by cytokines, which activate various signaling pathways, such as p38, JNK, ERK and TGF-β/SMAD [22], [33], [34], [35], [36].
We have predicted novel molecular regulators (unique genes and interactions) which could have an impact on the pathophysiology of T2D and its complications via various significant pathways such as insulin signalling, oxidative metabolism, Wnt signalling and others.
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