This genomic region contains paternally expressed imprinted genes and maternally expressed miRNAs, with many of these miRNAs differentially expressed in several pathologic processes and various cancers (Benetatos et al., 2013).
Microbiome plays a key role in homeostasis and affects several pathologic processes, including diabetes (Ussar et al., 2016).
PPROM has been associated with several pathologic processes [ 4, 5].
Activation of the low-affinity PGE2 receptors is likely to be important in mediating the actions of the much higher concentrations of PGE2 found in various pathologic inflammatory processes [ 36].
Angiogenesis is a highly-controlled process that is dependent on the intricate balance of both promoting and inhibiting factors, involved in various physiologic and pathologic processes.
Recent studies have demonstrated that autophagy is involved in various physiologic and pathologic processes including cancer, cardiovascular disease, metabolism, viral infections and immune response, etc. (Deretic, 2012; Levine and Deretic, 2007; Mihaylova and Shaw, 2011; Shintani and Klionsky, 2004; Yang et al., 2011).
Autophagy and apoptosis are often co-activated in response to stress and both have been implicated in various physiologic or pathologic processes including cellular differentiation and cell death [16].
DOI: 10.1038/sj/bjc/6600183 www.bjcancer.com © 2002 Cancer Research UK Prostaglandin endoperoxide H synthase (also referred to as cyclooxygenase (COX)) is the rate-limiting enzyme in the production of prostaglandins (PG) and thromboxanes, which are involved in various physiologic and pathologic processes such as inflammation, angiogenesis and development of cancer.
Reviewer 1 raised the following major issue: The current paper presents the discovery of a pair of cell surface receptors for PEDF, a peptide that is reported to exert a bewildering array of different actions on various cells and pathologic processes.
