The pathophysiology of brain dysfunction, among the various organ dysfunctions, remains poorly understood.
Severe HLH is commonly accompanied by various organ dysfunctions including manifestation of acute kidney injury (AKI).
The course of various organ dysfunctions and supportive treatments like vasoactive drugs, ventilator, and steroid therapies were also recorded.
An increase in IAP is associated with various organ dysfunctions (local and systemic), which in turn are associated with significantly increased in morbidity and mortality [ 1].
Whereas in the past patients may have received a few drugs to support single organ failure, nowadays it is not uncommon for patients to be receiving more than 10 drugs simultaneously to support their various organ dysfunctions.
For example, atopic disease, which affects approximately 30% of the population, includes food allergies that may cause various organ dysfunctions, thus implying that the link between constipation and atopy may be explained by food allergy.
Another unresolved possibility is that GH action in early-life may predispose various organ systems to dysfunction in mid- to late-life, thereby contributing to WAT dysfunction and senescent cell accumulation with aging.
A detailed analysis of the influence of the various severities of organ dysfunction has not been conducted in these studies.
A relation of PCT and various severities of organ dysfunction has been published previously, supporting the observation of organ dysfunction and systemic inflammation-related induction of PCT and CRP.
The scoring system in ICU should assess various degrees of organ dysfunction starting from normal function to organ failure; assessment of organ dysfunction needs to be based on simple, easy repeatable variables specific to the desired organ, readily available and able to reflect the dynamic changes of illness over time [ 2].
