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Neurotrophins acting through their specific tyrosine kinase receptors (RTKs), TrkA (for NGF), TrkB (for BDNF and NT-4) and TrkC (for NT-3) have been involved in multiple biological processes, including survival, migration and neurite outgrowth of various neuronal populations.
Hyperoxia causes apoptotic cell death in the developing brain and there is a time window within which various neuronal populations are more vulnerable to hyperoxia-induced cell death [9].
However, although many immunohistochemical studies have identified and characterised the various neuronal populations involved in Type II FCD, its aetiology and pathogenesis are unknown.
We would like to emphasize that only when this case was studied at the cellular and tissue levels, it was possible to unravel the significantly different sensitivity of various neuronal populations to TPP1 deficiency in the described genotype.
Of interest, it has been demonstrated in a murine model that the intracerebral administration of human anti-ribosomal P can induce depressive behavior, with staining of antibody to various neuronal populations [ 45].
Moreover, because DNA methylation is a distinguishing feature that varies between cell types, specifically various neuronal populations, the variation in methylation (hypo/hyper) profile of our sample may be due to the cellular heterogeneity of the cerebral hemisphere [ 56- 58].
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Several neuronal populations require Bax for cell death during development.
We conducted extensive immunohistochemistry (IHC) in tissue from C9ORF72-ALS cases to determine the distribution of each species of RNA foci within various CNS neuronal populations known to degenerate in C9ORF72-disease [ 19].
Together these data suggest that, although sense and antisense RNA molecules might be expected to be equally toxic via their shared protein binding partners, distinct patterns of expression in various CNS neuronal populations could lead to relative differences in their contribution to the pathogenesis of neuronal injury.
For example, it has been demonstrated that neuronal populations express various levels of Htt protein.
Various physiological and pharmacological stimuli have been shown to induce Fos-IR in specific neuronal populations located in various regions of the brain.
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