In patients, the various mutations in the HSPB1 gene result in differences in the severity of the disease, the involvement of the sensory and motor functions and the age of onset, which may also suggest differences in the pathomechanisms involved.
Differences in the presence of the various mutations among the populations of Monte Alegre, Prainha, and Alenquer were not statistically significant (P > 0.10).
In other words, it represents a summary of the allele frequencies of the various mutations in the sample.
Next, we determined the effect of various mutations within the ERSE motif on the activity of the mouse ALG12 promoter.
These models can be used to test the influence of various mutations on the dynamics of the ion channels.
Therefore, it is still very difficult to predict the effects of various mutations on the structural and functional properties of the mutated protein, although many studies have been done to predict the effects of AA substitutions on protein functions [168].
Myriad has run over a million BRCA tests since their creation of the test in 1996, and they have a treasure trove of information on the various mutations and the BRCA population that could have profound implications on medical research and treatment for the entire cancer community.
The disorder is caused by mutations in alpha-l-iduronidase, but the various mutations in the enzyme and unknown modifiers cause three different phenotypes, known, in descending order of severity, as Hurler's, Hurler-Scheie and Scheie's syndromes.
In addition, the effect of various mutations on the survival of bacteria in the presence of ROS and oxygen has been evaluated in a number of other studies [ 22- 28].
