Sentence examples for various mutant forms from inspiring English sources

Equivalent expression of the various mutant forms of hTTP is documented in Fig. 4A1 (lanes 2 6).

In order to investigate the functional relationship between Apm1 and Rho3 signaling, we constructed various mutant forms of Rho3 and examined their effects on the Δapm1 cells.

To better define the biochemistry of PARP-dependent mADPR formation, we reconstituted PARP-1 deficient DT40 cells with either WT or various mutant forms of PARP-1 (Figure 2), and determined the capacity of each mutant to support two correlates of O/N stress-induced mADPR formation: NAD degradation and TRPM2 activation.

Indeed, our recent data using various mutant forms of TG2 supported this contention.

Left panel, WT and various mutant forms of CPAP937 1124 binding to WT STIL404 448 (T986 is a non-interacting residue included as a negative control).

It has also been reported that various mutant forms, such as LRRK2(R1441C) and LRRK2(Y1699C), accumulated within cytosolic pools that were suggested to comprise aggregates of misfolded protein [ 11].

To test whether this mutation perturbed the interaction with STIL, we purified WT and various other mutant forms of D. rerio CPAP937 1124 in which we valine substituted residues that our crystal structure suggested to be important for binding.

Heat shock protein-90 (Hsp90), a component of a multi-chaperone complex, plays a key role in the stabilization and maturation of various wild type and/or mutant forms of proteins, such as EGFR, c-Met, ErbB2, Raf1, and Akt.

It should be noted that computational studies of enzyme selectivity are made particularly challenging by the very small energy differences between various substrates and between mutant forms of the enzyme as well as the long simulation times required to obtain convergent free energies (see, e.g., refs (15) and (16)).

Similarly, expression of inactive mutant forms of various growth factor receptors reduces activation of ERK by oxidative stress [ 34], while over expression of certain normal growth factor receptors in rat PC12 cells exposed to H2O2, results in enhanced activation of ERK [ 37].

Therefore, we used glutaraldehyde crosslinking to examine whether the various Hsp104 mutants formed hexamers.