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In various murine models of diet-induced obesity and type 2 diabetes, C29 induced significant improvements in insulin sensitivity, glucose tolerance, and reduced triglyceride levels73.
To address this issue, we studied the impact of PAI-1 deficiency in various murine models of tumoral lymphangiogenesis.
Various murine models of cardiac arrhythmia have been developed, such as those with Na+ channel defects and autonomically driven arrhythmias associated with engineered defects in Ca2+ handling.
Over the years, there has been some debate as to the validity of using various murine models for studies of DMD.
Finally, an impressive series of previous observations clearly demonstrated a pathogenic, rather than protective, role of IFN-γ in various murine models of autoimmune disorders [ 52- 60].
TGFβ signaling inhibitors have been shown to prevent EMT, to inhibit mammary tumor viability and to block metastasis in various murine models [ 70].
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The effects on inflammation and cartilage integrity have been evaluated in various murine arthritis models, but not in OA models or defect models.
Among the various murine arthritis models, the K/BxN serum transfer model is a suitable in vivo system for exploration of the complex cellular and cytokine network in the effector phase of antibody-induced arthritis [ 12].
Immune response against circumsporozoite protein (CSP) of Plasmodium berghei, a major surface protein on the sporozoite, confers protection in various murine malaria models.
However, the role of Panton-Valentine leukocidin (PVL) in the pathogenesis of CA-MRSA infection is currently a matter of much debate because of conflicting data from epidemiologic studies of CA-MRSA infections and various murine disease models.
Analyses of B-cell signaling in various murine lupus models have not only provided an in-depth perspective of the signaling status and possibly the underlying mechanisms leading to enhanced survival of autoimmune B cells, but have also presented us with potential strategies for treating lupus.
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