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Functional classification of these genes by GO revealed their involvement in various molecular functions and biological processes (Table 3 and Additional file 5).
Cytotoxic drugs were designed to kill tumor cells, whereas agents of molecular targeted therapy inhibit various molecular functions of the tumor cell.
Supplementary Table S3 shows the classification of 98 proteins into the various molecular functions.
Proteins targeted by SARS either directly or via other proteins are involved in various molecular functions and pathways such as apoptosis, cell communication and signalling pathways.
In principle, various molecular functions in rRNA maturation and transport can be envisioned for r-proteins as for ribosome biogenesis factors.
Figures 3A and B depict respectively the fraction of TNFα induced up- and down- regulated genes in HepG2 cells among the various molecular functions as identified by the GO Tool Box.
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The third group was related to various molecular function terms dealing with binding (12 genes).
The target genes for the differentially expressed miRNA include genes of various molecular function such as metal ion binding, sodium-potassium ion, transcription factors, which may play key role in reducing I/R injury.
Distribution of S. hexandrum unigenes across various molecular function categories revealed prominent up-regulation of several genes including for protein kinase activity, and calcium ion binding at 15°C.
The functions of the identified genes cover various molecular function categories, and the well-represented categories included plasma membrane, integral membrane, nucleotide binding, structural component of ribosomes and nuclear proteins.
Although sixty nine genes of rice were found without any GO annotation but percentage of genes predicted under various molecular function and biological process categories were similar for both rice and Arabidopsis probably indicating towards the high conservation of DRR process.
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