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8, 9 Research in the field grew as the percentage of women infected with HIV increased, especially in Sub-Saharan Africa, where 67% of the HIV-infected individuals worldwide live. 1 Unfortunately, over the past decade, research into various microbicides has not yielded compelling data for their efficacy.
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The authors are also indebted to all the participants of the various microbicide trials.
The ethical concerns outlined in this paper will therefore apply differentially to the various investigational microbicides in clinical trial development.
Of the numerous microbicides in various stages of clinical testing, some are expected to be locally absorbed only while other agents, such as Tenofovir gel, have already shown evidence of systemic absorption [ 14].
Almost 60 potential types of microbicide are at various stages of development around the world.
However, a wide range of microbicide gels are in various phases of clinical trial testing necessitating on going reflection on the ethics of microbicide research internationally [ 8- 12].
Numerous new barrier contraceptive methods and microbicides are currently in various stages of development and testing.
Susceptibility was evaluated in progestin-treated mice by delivering a low-dose viral inoculum (0.1 ID50) at various times after delivering the candidate microbicide to detect whether the candidate increased the fraction of mice infected.
Several trials of candidate microbicides have had disappointing outcomes [3] [7].
Analysis was done using STATA version 10. Analysis was performed to describe the socio-demographic background of respondents, proportion of respondents accepting to use microbicide and the preference for various formulations and other attributes.
Polyanions, including heparin and various other glycosaminoglycans, have been investigated as HIV microbicides for decades, as they are also thought to exert direct anti-HIV activity by inhibiting the binding of the viral envelope glycoprotein, gp120, to its major cell surface receptor CD4 (Callahan et al., 1991; Rider, 1997; Witvrouw and De Clercq, 1997).
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