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Upon recognition of pathogen-associated molecular patterns [8] or molecules released by damaged host cells, referred to as "danger signals" [9], macrophages manifest a strong inflammatory response characterized by secretion of various mediators like TNF-α, IFN-γ, IL-8 and nitric oxide.
TCIPA can occur via direct contact with tumor cells or by various mediators like ADP, thromboxane A2, or serine proteinases, including thrombi [ 19- 21].
The injurious effect of absolute ethanol in the stomach as a result of superficial aggressive necrosis due to enhanced lipid peroxidation also involves various mediators like lipoxygenase, cytokines [ 15], and excessive generation of oxygen-derived free radicals [ 16].
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Due to nociceptive stimulation, various mediators are produced like prostaglandin, cytokinin, bradykinin, and so forth, producing acute pain and inflammation.
Baicalin may protect against IRI by altering the production of various mediators, including reactive oxygen species (ROS), Toll-like receptor (TLR 2 and TLR4, NF-κB, Bax, and Bcl-2.
The inflammatory processes activated by toxic agents like PCM produce various mediators, which are involved in the production of ROS and NO that can affect liver damage or repair.
The various mediators persuaded the family members to put the matter to a vote.
The plasma contains four interrelated systems of proteins complement, the kinins, coagulation factors, and the fibrinolytic system that generate various mediators of inflammation.
After an acute infarction, CCN2, activated by various mediators including TGF-β1, plays a role in regulation of fibroblast phenotype and function in the injured area18.
Airway fibroblasts were treated with various mediators including IL-13 and specific MMP-inhibitors.
Various mediators and mechanisms linking to metabolic diseases have been postulated.
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