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Finally, convergent data from various laboratories have shown that the mitochondrial energy reserve and ATP levels are significantly reduced in the brain of migraineurs between attacks [27, 28].
To date, various laboratories have developed and characterised a diverse set of C. elegans models of various human NDs, including AD [7], PD [8] and polyglutamine expansion diseases [9] (Table 1).
This is of obvious relevance because neuronal excitability depends on energy metabolism and because convergent data from various laboratories have shown that brain oxidative metabolism, mitochondrial functioning, and energetic production are significantly reduced in the brain of migraineurs between attacks [44 46].
The IFAT have been widely used, but the method is laborious and time-consuming, and discrepancies in interpretation of the results between various laboratories have been reported [ 30].
Several studies performed in various laboratories have demonstrated that 25 to 30% of all breast and ovarian malignancies show the amplification and overexpression of this gene [ 8, 9].
Various laboratories have used organs such as brain, kidney, and spleen to isolate the virus in cell culture, or to detect the virus by using a variety of techniques, or both (2 ).
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Converging evidence from various laboratories has indicated a lack of consistent effects upon HPA programming by maternal separation protocols in mice (Millstein and Holmes, 2007; Own and Patel, 2013).
Recent works from several laboratories have identified various serum markers and cellular markers in predicting mortality and morbidity in a wide variety of diseases, such as cardiovascular disease and tumor pathologies [13] [15], [21] [23].
Studies from several laboratories have described the presence of various autoantibodies in these fluids [ 10– 13].
Several laboratories have reported ~30 100% increases in plantaris muscle mass following various durations of compensatory hypertrophy [ 25].
In a joint effort with various laboratories we have been aiming at the structure-based design of glycolysis inhibitors as anti-trypanosomal drugs.
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