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Recent studies demonstrate that they achieve their antimicrobial activity by disrupting various key cellular processes.
Even though the Duchenne muscular dystrophy (DMD) gene product Dystrophin Dp71d is involved in various key cellular processes through its role as a scaffold for structural and signalling proteins at the plasma membrane as well as the nuclear envelope, its subcellular trafficking is poorly understood.
The newly discovered protein, TBLR1, plays a crucial role in regulating various key cellular functions.
Among the down-regulated pathways, biological processes and molecular functions related to protein ubiquitination, a versatile process regulating various key cellular events such as DNA repair, cell cycle, and apoptosis [ 26], were the most intriguing findings.
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In the cellular component category, several key cellular components were identified, such as cell part, membrane and ribosome.
ROS are damaging to several key cellular components, including mitochondria.
Hundreds of proteins with various defined key cellular functions were identified from TNBC and non-TNBC tumors.
The phosphoinositide 3-kinase (PI3K) pathway is a very important signal transduction system that is bound up with oncogenes and various receptors to regulate many key cellular functions, such as proliferation, differentiation, migration, trafficking, apoptosis and glucose homeostasis [[ 94]].
Measurement of specific end points includes cell survival, cell death, or various biochemical parameters, allowing identification of the key cellular mechanisms.
Treatment with a conjunction of agents that target key cellular mechanism or proteins critical for various cancers are being investigated against a variety of tumors.
Tax protein contributes to the initiation of T-cell transformation through various mechanisms, by deregulating the function and expression of key cellular factors involved in cell growth and proliferation, apoptosis, DNA repair, and cell division (Matsuoka and Jeang 2007).
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