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OPN biological activity is modulated by differential splicing, translation, glycosylation, phosphorylation, and/or proteolysis that can give rise to various isoforms, as has been shown in other systems [23] [28].
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Figure 3b illustrates the presumed structure of these various ER isoforms, as well as their sizes as determined by SDS-PAGE.
This article reviews the evidence that the joint synovium of patients with rheumatoid arthritis (RA) contains considerable amounts of various CD44 isoforms as well as the HA ligand.
Fibronectin exists in various isoforms, generated as a result of alternative splicing thereof due to combination of these spliced variants, corresponding to extra domain A (EDA/EIIIA), extra domain B (EDB/EIIIB), and connecting segment III (V).
Fibronectin exists in various isoforms, generated as a result of alternative splicing of pre-messenger RNA at three distinct sites including extra domain A (EDA/EIIIA), extra domain B (EDB/EIIIB), and connecting segment III3.
Selected protein spots were assessed with MALDI-TOF MS and were identified as various isoforms of amyloid and haptoglobin, as well as the H1a-A2 protein (Fig. 2c).
Furthermore, compounds 13s and 14a exhibited low inhibition profiles for various human cytochrome P450 isoforms as well as excellent blood plasma stability.
In plants, genes encoding NADP-me form a small multigene family, whose different gene lineages encode various isoforms involved in nonphotosynthetic functions as well as in CAM or C4 pathways (Cushman 1992; Edwards and Andreo 1992; Honda et al. 2000; Drincovich et al. 2001; Lai, Tausta et al. 2002; Lai, Wang et al. 2002; Gerrard Wheeler et al. 2005, 2008; Müller et al. 2008).
Thus, monomeric Aβ peptides encompass various isoforms, including Aβ 1-40), Aβ 1-42), and Aβ 1-43), as well as numerous N-terminal truncated isoforms.
The VEGF pre-mRNA is transcribed from a single gene containing 8 exons, is spliced and expressed as various isoforms owing to alternative splicing of exon 6 and 7.
It activates gene expression via direct binding to different nuclear receptors that are expressed as various isoforms during embryogenesis.
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