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While various isoforms are expressed throughout the body, the kidney and liver have been observed to express the highest levels of ALDH.
Various phospholipase enzymes are involved in degradation of PtdCho to GPC, PCho, and Cho but the roles of the various isoforms are still not fully elucidated.
However, the serotype-specific protection conferred upon the fish by agglutination/immobilization antigens as shown by Hatanaka (2008) [ 63] and the existence of various isoforms are some obstacles that need to be overcome before this protein can be developed and used as a vaccine against C. irritans.
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Expression of the various isoforms is tightly regulated by cell type and state of activation.
Multiple, alternatively spliced isoforms of Abi1 are expressed in mammalian cells, but the functional significance of the various isoforms is unknown.
The sequence similarity among the various isoforms is about 50 80%; the transmembranal helices are particularly well preserved [ 21].
Skp1 and its various isoforms were purified essentially to homogeneity and extensively dialyzed simultaneously against CD buffer [20 mM sodium phosphate (pH 7.4), 50 mM NaCl, 1 mM MgCl2, 0.1 mM EDTA, and 1 mM TCEP].
Multiple alternatively spliced transcript variants of the RBMS3 gene that encode various isoforms have been found.
In normal brain, various dystrophin isoforms are expressed, but little is known about their function.
Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies.
Moreover, the predicted aggregation propensities of the various peptide isoforms are essentially identical (supplementary material Table S2).
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