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Mutation or aberrant inhibition of the TSC complex is common in various human tumor syndromes and cancers.
In preclinical studies, erlotinib has substantial antitumor activity against various human tumor xenografts alone and in combination with chemotherapeutic drugs.
Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.
Representative compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in various human tumor cells.
Most tested compounds exhibited good inhibitory activities against aurora A kinase and various human tumor cell lines.
MVL-PLA2 was not cytotoxic up to 2 μM and completely abolished cell adhesion and migration of various human tumor cells.
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Drug concentrations measured in sonicated brain tissue corresponded with cytotoxic levels measured in vivo in various human tumors.
The gastrin-releasing peptide receptor (GRP-r) is over-expressed in various human tumors.
Iron is suspected to be involved in the induction and/or progression of various human tumors.
The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various human tumors and represents a valid target for anticancer drug design.
Src kinase, a prototype member of the Src family of kinases (SFKs), is over-expressed in various human tumors, and has become a target for anticancer drug design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com