Anticancer drug resistance almost invariably emerges and poses major obstacles towards curative therapy of various human malignancies.
Drugs, which target thymidylate synthase and folate-dependent enzymes, represent an important therapeutic arm in the treatment of various human malignancies.
Therefore, dysregulation of HGF/c-Met signaling can compromise the cellular capacity to moderate these activities and can lead to tumorigenesis, metastasis, and therapeutic resistance in various human malignancies.
Side population (SP) assay composed of Hoechst 33342 staining and subsequent flow cytometric analysis has been widely utilized for characterizing putative cancer stem cells (CSCs) in various human malignancies.
Here, we used simplified systems bearing physiological relevance to examine the impact of gossypol on the function of MCL-1, a key determinant for survival of various human malignancies that has become a highly attractive target for anticancer drug design.
Antibody-based therapy of various human malignancies has shown efficacy in the past 30 years and is now one of the most successful and leading strategies for targeted treatment of patients harboring hematological malignancies and solid tumors.
For example, NY-ESO-1 and MAGEA3 are currently undergoing clinical trials in various human malignancies, including NSCLC.
The FOXO transcription factors have been shown to be constitutively activated in various human malignancies, including prostate cancer [39], [56].
In Asian, PL is one of well-established medicinal mushrooms that have been using to treat various human malignancies.
As mentioned above, the difference in tumor proliferation was assessed by Ki-67 staining, a commonly employed proliferation marker with prognostic value in various human malignancies including breast cancer [52], [53].
Although NY-ESO-1 and MAGEA3 are currently undergoing clinical trials in various human malignancies, including NSCLC, the use of single antigen vaccine formulations have often been met with limited clinical outcomes [14], [15], [16], [30].
