Because of the lack of uniformity in the annotation of CGs across the various human genome resources (UCSC, GenBank, Ensembl, Vega), we realized that there was a need for a dedicated and comprehensive repository for such genes.
Large amounts of data on the human genome as well as on various human cancer genomes have been obtained in recent years by genome-wide sequencing, genome-wide expression analysis (DeRisi et al., 1996; Schena, 1996), proteome analysis, genome-wide copy number analysis as well as by combinations of these methods (Green et al., 2011).
In recent years, numerous efforts have been made to identify gene mutations in various human cancers by genome-wide or large-scale sequencing [3], [4], [5], [6], [7], [8], [9].
In this context, detailed studies combining population genetic approaches making use of the massive whole-genome sequence-based data sets for various human populations, such as the 1000 Genomes Project (1000 Genomes Project Consortium 2010; Abecasis et al. 2012), and genome-wide association studies of multiple diseases and other traits of interest are now required.
In normal human genomes, various single nucleotide polymorphisms in the mcm genes are commonly observed (http://www.ncbi.nlm.nih.gov/projects/SNP/).nih.gov/projects/SNP/
Real-time PCR techniques are now commonly used for the detection of viral genomes in various human specimens and require for validation both external and internal controls (ECs and ICs).
In humans, 19 unique ZF repeats have been identified by extensive analysis of genome sequences from various human populations.
To evaluate the sensitivity and accuracy of the various alignment algorithms, we simulated from the human genome various 50 base-pair read classes.
The mutation and/or transmission of paternal mitochondrial genome are associated with various human diseases.
B19V genomes were previously shown to persist in various human tissues, both in healthy individuals and patients [32].
