Two astronauts, Angela and Tommy, are marooned on an eerie non-solar planet; the action takes place six generations later, by which time, as well as various genetic problems caused by in-breeding, their descendants have developed a kind of ancestor-worship mythology.
Over the last two decades, a growing number of scientific evidences highlighted the potential therapeutic value of several structures of aminoglycoside antibiotics (including gentamicin and G418) for the treatment of various genetic diseases caused by nonsense mutations.
There are various acquired and genetic causes that should be ruled out in patients with the symptom of spastic paraplegia without a family history (Table 1).
The control of body size depends on the integration of various genetic and environmental causes that operate through complex molecular and physiological mechanisms [ 20, 38, 39].
Hypokalaemia in hypertensive patients is a 'red flag' bringing to mind various classic secondary and genetic causes related to both hypokalaemia and hypertension.
Results indicate that tooth agenesis appears to be a genetically controlled anomaly related to the orofacial cleft development through various genetic links and not caused by the cleft disruptive process.
The intrinsic threats to DNA integrity, including DNA replication errors, spontaneous hydrolytic reactions, and reactive oxygen species (ROS), together with exogenous physical (e.g. UV/IR radiation), chemical and biological agents (e.g. virus) cause various genetic lesions, such as point mutations, translocations, chromosomal gains and losses, telomere shortening, and gene disruption.
Furthermore, IS elements are capable of causing various genetic rearrangements such as deletions, inversions and translocations [ 19, 20].
Our data show that various genetic manipulations expected to cause loss of Rad9 binding to histone H3 lead to an increase in the speed of resection both at DSBs and uncapped telomeres, suggesting that chromatin-bound Rad9 could represent a functional or physical barrier to exonucleolytic processing of DSBs and uncapped telomeres.
Familial hypercholesterolemia (FH) is a hereditary condition caused by various genetic mutations that lead to significantly elevated low-density lipoprotein cholesterol levels and resulting in a 20-fold increased lifetime risk for premature cardiovascular disease.
