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Sebastiani and Perls subsequently said they had not realized that the microarray technology they used to identify the various gene variants had certain limitations.
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According to the presence of various GST gene variants in combination, ESRD patients may be stratified in level of oxidative, carbonyl and nitrosative stress.
The aim of the study was to examine the association between weekly alcohol intake and diabetes and CHD risk factors in relation to various ADH and ALDH gene variants.
One important aspect of current genetics research is the identification of groups within populations that carry polymorphisms in various genes, resulting in gene variants called alleles.
The concept of multifactorial etiology of BEN anticipates that a combination of polymorphic gene variants and various environmental factors causes an increased risk for the disease.
Associations of various vitamin D receptor (VDR) gene variants and MS were also reported (23- 25).
The hypothesis of a multifactorial aetiology of BEN anticipates that an interaction of polymorphic gene variants and various environmental factors causes an increased risk of renal disease and cancer [ 77].
Identified gene variants point towards various molecular pathways, e.g. neuronal dysfunction, vascular integrity and function, and pain signaling.
Systemic basal circulating CRP levels are genetically determined and influenced by a number of loci including CRP gene variants per se in various ethnic groups (Martínez-Calatrava et al. 2007; Reiner et al. 2012).
The reasons were various (e.g. sample size, other gene variants, and different pathological mechanisms of 5-HTTLPR in anxiety and depression) and should be explored in future.
Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG).
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