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Upon infection, antigen-specific T lymphocytes become activated, proliferate, differentiate, and acquire various effector functions.
Furthermore, DARPins can be engineered to carry various effector functions or combine multiple binding specificities, enabling completely new drug formats.
Future experiments should shed light on the specific mechanisms by which the various effector functions of the Sestrins are achieved.
In addition to their recruitment to sites of infection and various effector functions, they also have strong anti-inflammatory properties.
PI3Kγ is known to control various effector functions of leukocytes, including migration (e.g. extravasation from blood to tissue), oxidative burst, cytokine production and phagocytosis [ 8- 19, 19, 20].
Additional studies are needed to verify this observation and to elucidate the underlying mechanisms, for example, the generation of plasma cells with their various effector functions and other factors.
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NK cells are one of the most important cell populations of innate immune system with diverse effectors functions like killing the tumor cells and virus-infected cells as well as secreting various cytokines.
For example, within the broad range of various M1 effector functions, RBP-J predominantly focuses on the "bacterial host defense" module by targeting IL-12 and iNOS with minimal impact on "acute inflammation" module by sparing IL-1β.
Type 1 interferons (IFNα/β) are expressed rapidly in response to viral infection, and, in turn activate many interferon stimulated genes (ISGs) which exert various antiviral effector functions.
The strength of the various immune effector functions varies depending on the specific isotype of monoclonal IgG antibodies used in the ADC.
Stimulation of monocytes by interaction of monoclonal antibodies (mAbs) with Fc gamma receptors (FcγRs) results in the activation of various monocyte effector functions.
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