Sentence examples for various downstream targets from inspiring English sources

Previously, various downstream targets of NO have been shown to be inhibited by Aβ (18, 19).

cAMP activates protein kinase A (PKA) by binding to the regulatory subunits of PKA, releasing the catalytic subunits from inhibition, and allowing the phosphorylation of various downstream targets, including Lck [20].

The unique role of SALL4 in the self-renewal properties shared by ESCs, HSCs, and LSCs could be associated with its ability to recruit epigenetic modulators to regulate various downstream targets in various stem cells.

BAs and FXR not only interact with each other but also regulate various downstream targets independently during liver regeneration.

Activated p53 protein has various downstream targets, including genes involved in cell-cycle regulation, apoptosis, and DNA repair.

These distinct MAPK pathways share several common upstream kinases and various downstream targets, suggesting they may crosstalk with one another in various contexts [ 18].

One of the mechanisms by which the AP2 family fulfills their roles is to activate or suppress various downstream target genes at transcriptional levels.

The binding of CD2AP to p85 activates the PI3K/Akt signal pathway, which then phospho-activates and phospho-inhibits various downstream target proteins.

Forkhead box O (FoxO) transcriptional factors regulate various downstream target genes, including those involved in cellular differentiation, growth, survival, the cell cycle, glucose and lipid metabolism, stress, and the detoxification of reactive oxygen species (ROS) [ 16].

Activated RSK2 transduces its activation signal to various downstream target proteins including transcription and epigenetic factors [ 10– 12], kinases [ 13], and scaffolding proteins such as nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor α (IκBα) [ 14], and regulates diverse cellular activities involved in cell proliferation, transformation and motility [ 15].

It is unclear whether dPGC-1 mediates some of the longevity-enhancing effects of AMPK (Fig. 1); nevertheless, further studies in Drosophila, focusing on how disruption of various putative downstream targets of AMPK affect AMPK-mediated lifespan extension, should help resolve the AMPK targets responsible for lifespan extension.