Sentence examples for various downstream effects from inspiring English sources
Detailed analysis of all genes suggested that a defect in the splicing of the U12-type intron of the mitochondrial prohibitin gene may be the primary cause of the various downstream effects detected in the microarray analysis.
The data therefore suggest that pollen deprivation may cause normal age-related transcriptional regulation to go awry, leading to various downstream effects.
Additional work will be needed to determine the exact role of the various downstream effects of ROS in altering contractile protein function in hyperglycemia and to also evaluate the specific mechanisms responsible for the observed depletion of troponin.
Taking the structural perspective, the repeated sequences within DNA become transiently single-stranded during DNA replication, recombination, repair and transcription, which allows non-B-DNA structure formation and various downstream effects [ 20].
Activation of NF-κB, AP-1 and JAK3/STAT mediates various downstream pathological effects of LMP1 expression [ 5].
The mobile nature of NO and its chemical reactivity with various cellular targets means that downstream effects of NO may be directly induced by interaction with various cellular components, like ion channels or proteins that modulates gene expression, or indirectly following interaction with signalling proteins such as protein kinases.
These results are further supported by other studies using embryonic stem cells and MSCs, suggesting that FN and LM-5 mediate the regulatory effects on various downstream targets via the FAK, Akt, PDGFR- β, and Erk signaling pathways.
Some studies suggest that ERK1/2 showed its apoptotic effects by targeting various downstream targets such as cMyc, Elk1 and p53 [ 53] whereas others suggest ERK1/2 mediated apoptosis is a result of balance between intensity and duration of pro- versus anti-apoptotic proteins [ 54].
Increased oxidative stress and its downstream effects can lead to various conditions such as cardiovascular diseases [ 67], Alzheimer's disease [ 68], aging [ 69], and cancer [ 70].
The new link between autophagy and senescence provides an insight into the diversified downstream effects of autophagy in various cellular contexts.
Given the myriad of downstream effects, its frequency of overexpression, and its correlation with prognosis, various approaches have been considered to inhibit EGFR, including monoclonal antibodies (MoAb) and small molecule inhibitors.
