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The main toxicity signs to PNPC and PNP in various doses are summarized in Tables 1 and 2 and Supplemental Tables 1 5.
In a previous study conducted at the Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation (CMCRC/ERF), we demonstrated for the first time that aspartame (APM) is a multipotent carcinogenic agent when various doses are administered with feed to Sprague-Dawley rats from 8 weeks of age throughout the life span.
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Surprisingly, the γ-FBS solutions irradiated at various doses were also shown to inhibit NLP formation in the same manner (Fig. 7A, "5-to-50 kGy").
Quantitative values for induction and repair of DSBs at various doses were determined by pulse-field gel electrophoresis (PFGE) and the formation and disappearance of γ-H2AX foci [45], [49], [50], [51].
Linearity in PK response of various doses was assessed by applying the power function P = A*Dose b to non-normalized Cmax and AUC0- t values of zolpidem.
Atorvastatin and rosuvastatin at various doses were compared most often (n=61), followed by pravastatin and placebo (n=35), simvastatin and placebo (n=18), and atorvastatin and placebo (n=24).
Average blood levels achieved by the various doses were 4.2-620 ng/mL for o,p'-DDT and 5.0-300 ng/mL for ss-HCH.
Samples of E. coli ATCC 25922 in tissue-cage fluid after treatment with various doses were examined for susceptibility to cefquinome.
Cells frozen at 4 h after irradiation with various doses were thawed on ice and RNA was extracted using Aurum Total RNA Mini Kit (BioRad, Hercules, CA, USA) as per manufacturer's instructions.
In the present study, vehicle or risedronate at various doses was administered to 17 19 week old female C57BL/6 mice and changes in the structure of the tibiae three-dimensionally analyzed by high-resolution μCT.
Thus, probably various ghrelin doses are required to activate various cellular pathways.
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