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Such experiments proceed by controlling various dose levels of the compound to groups of animals.
To determine local tumor control after CT-guided brachytherapy at various dose levels and the prognostic impact of extensive cytoreduction in colorectal liver metastases.
Details of toxicity at the various dose levels are illustrated in Table 2.
The horizontal lines represent the variation in systemic exposure at various dose levels.
This might be due to the heterogeneous study population and the various dose levels used in this study.
In 25 evaluable patients, eight (32%) achieved a partial remmission and 14 experienced stable disease at various dose levels.
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We did not perform additional experiments with various dosing levels of BDEs and different exposure periods; our primary focus was to determine if metabolism was consistent among hepatocytes harvested from three different individuals, providing insight into expected metabolic capability among the general population.
In contrast to patient derived tissues these in vitro models can be exposed to drugs at various dose-levels and multiple time-points in a well-controlled laboratory environment.
Grade 3 or 4 neutropenia was the most common haematologic toxicity observed, with incidence ranging from 17to87%7% of treatment courses at various irinotecan dose levels.
A summary of the neuropathic toxicities reported at the various dosage levels is provided in Figure 2. As anticipated, neutropenia was the major dose-limiting toxicity.
This hypothesis was evaluated in a phase I study with various low-dose levels of 5-AZA-CdR in patients with MDS or leukemia [ 11].
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