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These differentiating agents activated various signaling pathways, thereby inducing various differentiated phenotypes and all resulting in decreased tumorigenicity.
We investigated the patterns of expression of the Oct4-associated data set in cells at different stages of differentiation, including embryonic carcinoma, embryonic stem cells, embryoid bodies, and various differentiated cell types, on the basis of transcriptomics data (Campbell et al., 2007).
Later in development it is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle.
Direct reprogramming technology can convert various differentiated cell types to other fates by the forced expression of lineage-specific transcription factors.
Here, we review the recent results establishing some link between replication domains and chromatin structural domains in pluripotent and various differentiated cell types in human.
Generalized schematic representation of a tumor, showing both components that make up the malignancy: Mutated tumor cells, both putative tumor stem cells in their niche (11) and various differentiated subclonal populations (5), which can be in direct competition (8).
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As an intermediate cell migrates through the basal layer, it differentiates into various terminally differentiated cell lineages of prostate epithelium.
HSCs continually renew themselves to maintain a pool of blood stem cells; however, upon stimulation by cytokines, HSCs give rise to multipotent progenitor cells (hematopoietic multipotent cells: HPCs) with restricted differentiation potential, which can further develop into various terminally differentiated blood cells.
Therefore, this method describes how prices of various highly differentiated land plots would be determined under conditions of perfect competition with the market in equilibrium.
To determine the identity of cells expressing PCGs, we analyzed the relation of cells expressing PCGs sFRP-2 and nlg-8 to various known differentiated cell types.
Such variations may depend on the influence of molecular defects in mitochondrial respiratory chain complexes I and/or IV (CI and/or CIV) on mitochondrial energy metabolism and oxidative stress in various terminally differentiated cell types in affected individuals.
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