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Each molecule consists of various copy numbers of the V3 CTL epitope on HIV-1 gp120 (one, two, four and eight copies).
The strategy presented may be useful as a general approach for construction of stable production strains synthesizing natural products where various copy numbers for different genes are concerned.
We obtained four transgenic mice with various copy numbers of transgene (Fig. 1A).
Introduction of the resulting so-called pHG-PrP ("halfgenomic PrP") construct into PrP knockout mice resulted in lines with various copy numbers of the transgene which expressed PrP at different levels, not necessarily in proportion to the copy number.
In addition, other minor modes occur that represent the various copy numbers represented by the nuwts.
For the simulated 'normal' and 'disease' panels, standards were spiked at various copy numbers and ratios (Table 2).
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One way of doing this is to undertake a pathway analysis to link the genes in various copy number aberrations.
Finally, we used the clinical annotations available with the TCGA data to assess the correlation of various copy number features with survival.
West syndrome has been associated with mutations in ARX, CDKL5, STXBP1, and ST3GAL3 as well as various copy number variations (CNVs).
Demographic and clinical characteristics of the UNC tumors are provided in Supplemental Table 2.> > To identify subtype-specific CNAs from segmentation data generated by the various copy number array platforms (see Supplemental File 1 for details), we produced an add-on script to the SWITCHdna method of DNA copy number change point detection [ 13].
Of these, aCGH is highly useful to detect copy-number variations (CNVs) in the genome of individuals with apparently normal karyotypes [5,6], and MLPA can identify various copy-number alterations in specific disease-associated loci [7].
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