Sentence examples for various client proteins from inspiring English sources
The six long coiled-coil tentacles in the jellyfish-like chaperone prefoldin, for instance, are flexible, enabling it to adjust its central cavity and capture various client proteins (Siegert et al., 2000).
In an attempt to understand the differential cellular response of HSP90 inhibition by NVP-AUY922, the expression levels of HSP90, HSP70, various client proteins (EGFR1/Her1, ERBB2, AKT, and ER), and those involved in apoptotic responses (Bax, Bad, and Bcl-XL) were determined.
Client and variant specific changes in affinity may explain why there appears to be no good relationship between the activity that one specific variant shows with the various specific client proteins tested.
The novel inhibitors of Hsp90 can sensitize various tumor cells to apoptosis by destabilisation and depletion of several Hsp90 client proteins, thus causing the depletion of S phase and G2/M arrest by heat shock, increased DNA damage, and repair protraction and finally apoptosis [ 293].
HSP90 inhibition destabilizes various HSP90-client proteins, including JAK2 (Weigert et al., 2012; data not shown), therefore potentially negatively regulating JAK-STAT signaling.
These results demonstrate the presence of mixed disulfides between the various PDI proteins and endogenous client proteins.
Co-chaperones mediate various aspects of Hsp90 function, including the association of Hsp90 with client proteins and the regulation of Hsp90 ATPase activity [ 19, 20].
In the cytoplasm, Hsp90α has over 200 interacting proteins (hereafter referred to as "client proteins") [7] and it commonly functions in concert with various co-chaperones including Hsp70, Hsp40, Hop, Hip, and p23.
The activation of such proteins (client proteins) is regulated by the association of specific co-chaperones that complex with Hsp90 at various stages of the chaperone cycle [ 12, 13].
Many oncogenic client proteins involved in formation of metastatic pathways.
Stabilization, regulation, and maintenance of these oncogenic client proteins are provided with Heat Shock Protein 90 (Hsp90).
