Sentence examples for various cellular levels from inspiring English sources

It is well established that the transition from normal to neoplastic growth involves deregulation at various cellular levels including gene-specific mutational events, alterations in signal transduction and growth control pathways, and dysfunctional DNA synthesis and repair mechanisms resulting in the generation of chromosomal abnormalities.

Different growth factors trigger different reactions in the tissues of the periodontium at various cellular levels.

As mentioned previously, the RUNX proteins are transcription factors or repressors for various target genes, and their action might be modulated through many different signaling pathways exerting their affect at various cellular levels as well as at various developmental levels.

It has been widely established that hemodynamic and blood particle interactions with the vascular surface as well as surgical injury and compliance mismatch are inciting mechanisms capable of eliciting various cellular level responses associated with distal anastomotic intimal hyperplasia (IH) formation.

Although it is the proteins that are overwhelmingly responsible for the various cellular functions, expression levels of their precursors, mRNA molecules, provide considerable insights into the internal states of a cell.

8 10 Metabolites represent intermediate and end products of various cellular processes, whose levels can be regarded as a consequence of biological systems response to genotypic and environmental influences.

In an in vitro study with human MRC- 5 fetal lung fibroblasts treated with up to 80.0 μg mL SiO2 NMs (average diameter 45 nm; no indication of secondary particle characterization), Huang et al. (2012) recorded dose-dependent decreases of various cellular amino acid levels as well as glutathione accompanied with increased phospholipid and urea concentrations (making use of GC MS and LC MS).

There, S1P takes part in regulating various cellular processes and its levels are tightly regulated.

To detect potential changes of the ER stress related markers after expressions of various PrP mutants, the cellular levels of Grp78, CHOP and pro-caspase-12 protein were evaluated by individual Western blots.

The mechanism by which PRE084 induces neuroprotection was ascribed to the restoration of the calpastatin and NF- κB-p65 levels in huntingtin-expressing cells, which then upregulated various cellular antioxidants and decreased ROS levels with a positive effect on cell survival.

The present review highlights novel systems biology tools available to unravel the various cellular components on the level of metabolic and regulatory networks.