Sentence examples for various cellular effects from inspiring English sources

HDAC inhibitors have generated substantial interest as antitumor agents, because they induce various cellular effects, including apoptosis, cell cycle arrest and inhibition of angiogenesis.

The mechanisms that mediate the various cellular effects of TRPM7 in pancreatic cancer remain to be determined.

Recent recognition of JAK/STAT signalling pathways as inevitable molecular mechanism of various cellular effects of IFNs has elicited a considerable effort to elucidate the role of their components in cancer (Calo et al, 2003).

Consequently, the adaptive modulating the expression of nuclear genes such as metabolic enzyme genes and stress response genes leads to a compensation for the metabolic reconfiguration, in which various mitochondrial or cellular effects can be achieved (Fig. 2) (Butow and Avadhani, 2004).

An overactivated wt Ras may possibly alter various Ras-dependent cellular effects, including cell survival, proliferation, and differentiation, in ways so as to produce certain diseases such as cancer.

What are the cellular effects in various brain regions?

It is clear that ROS and oxidative stress have a central role, given their importance in various metabolic pathways and direct cellular effects, including in the disruption of endothelial glycocalyx, which may be relevant in pathogenesis of microalbuminuria.

In conclusion, our data demonstrate that a systematic genetic and functional dissection of apoptosis and cell cycle regulatory pathways in tumor cells reveals differential cellular effects in various antitumor treatment modalities that have a direct impact on cancer therapy.

Reoxygenation of the ischemic tissue promotes the generation of various reactive oxygen metabolites (ROM) which are known to have deleterious effects on various cellular functions.

Oxidized low-density lipoprotein plays a critical role in the pathogenesis of atherosclerosis and exerts pleiotropic effects on various cellular functions.

Phorbol esters, acting via activation of the protein kinase C family of protein serine/threonine kinases, are able to exert profound effects on various cellular functions.