Sentence examples for various cell signalling from inspiring English sources

SHP-2 closely interacts with the CagA protein, therefore, it is speculated that functional polymorphisms in the PTPN11 may mediate the interaction of this protein with its substrates and affect its regulatory role in various cell signalling events, such as mitogenic activation, metabolic control, transcription regulation, cell migration, and malignant transformation in H. pylori infected subjects.

These artificial sGAG derivatives altered several cellular processes such as various cell signalling pathways (e.g. BMP-2 (bone morphogenetic protein-2) and TGF-β1 (transforming growth factor-β1) signalling), proteins involved in endocytosis, cell-ECM-interaction, and ECM remodelling as well as matrix vesicle formation and composition13,14,15.

The current mode of treatment based on allopath is expensive and also alter the various cell signalling pathways.

Previous evidence suggests that soluble factors released by astrocytes bind to neuronal plasma membrane receptors inducing various cell signalling pathways.

Bortezomib is a 20S proteasome complex inhibitor that acts by disrupting various cell signalling pathways, thereby leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis.

In this review, we focused on the therapeutic role of green tea and its constituents in the management of cancer through modulation of various cell signalling pathways.

Furthermore, our data suggest that both Lyn and MCP-1 have crucial roles in balancing inflammatory response to bacterial challenge through interaction with various cell signaling proteins.

In addition, curcumin could affect cellular proliferation by modulating of various cell signaling pathways including NF-κB, growth factor receptor kinases and mitogen-activated protein kinases [16].

Further study is warranted to better address the interplay among various cell signaling pathways such as sirtuin, a key signaling molecule in longevity and lifespan [46], or RAGE, which plays a key role in aging-associated cardiomyocyte dysfunction via NFκB activation [47], in the aging- and obesity-associated cardiac contractile dysfunction.

Importantly, the sedimentation of growth-related mRNAs was also shifted to heavier polysomes: these include mRNAs encoding anti-apoptotic proteins; growth factors; various cell signaling proteins (kinases, phosphatases); transcription factors and proteins involved in growth and proliferation, mRNA processing, protein degradation and modification, cellular detoxification and transport (Table S3).

These indicate phthalate stimulates various cell signaling pathways of cancer cell migration and invasion.